The eighth-ranked Cubettes (29-3) will battle the sixth-ranked Lady Eagles (28-6) tonight at 6:00 at Hearne High School.
The Cubettes are coming off two hard-fought playoff wins, 63-56 over Pflugerville-Connally and 71-59 over Summer Creek.
The Lady Eagles dispatched Willis, 76-39 and Lumberton, 47-26.
The winner advances to the Region III/4A Semifinals, Friday at the Campbell Center.
The Brenham/Georgetown winner will face the winner of the Tomball/Rosenberg Terry game, tonight at 6:30 at Cy Ranch.
The other side of the bracket pits Montgomery against Beaumont Ozen, tonight at 6:00 at Channelview; and, Friendswood versus Goose Creek Memorial at 8:00 in Pasadena.