A Houston woman and a man from Austin were killed when their vehicle left the road at the 1100 block of Highway 36 North, just north of the clover leaf of Highway-290 and 36.
According to Brenham Police, the vehicle was north-bound on 36, when it left the highway and went airborne.
The vehicle landed nose-first and rolled over several times.
Pronounced dead at the scene was 31-year old Brandon Ray Southern of Austin.
38-year old Areeja Beagle of Houston died a short time later at Scott & White-Brenham Hospital. Both were ejected from the vehicle upon impact.
The investigation into the cause of the wreck continues.